KAP1 STABILIZES MYCN MRNA AND PROMOTES NEUROBLASTOMA TUMORIGENICITY BY PROTECTING THE RNA M6A READER YTHDC1 PROTEIN DEGRADATION

KAP1 stabilizes MYCN mRNA and promotes neuroblastoma tumorigenicity by protecting the RNA m6A reader YTHDC1 protein degradation

Abstract Background Neuroblastoma (NB) patients with amplified MYCN often face a grim prognosis and are resistant to existing therapies, yet MYCN protein is considered undruggable.KAP1 (also named TRIM28) plays a crucial role in multiple biological activities.This study aimed to investigate the relationship between KAP1 and MYCN Evaporator Plate Cl

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